Scientists Show How to Remove Gene Blockade and Boost Cognition in Alzheimer Disease

GEN News Highlights:Scientists Show How to Remove Gene Blockade and Boost Cognition in Alzheimer Disease: Scientists say histone deacetylase 2 (HDAC2)-selective inhibitors may represent a therapeutic approach to slowing cognitive decline in patients with neurodegenerative disorders such as Alzheimer disease (AD). Researchers at the Massachusetts Institute of Technology’s (MIT) Picower Institute for Learning and Memory and Howard Hughes Medical Institute found increased levels of HDAC2 in two mouse models of AD and in human AD patients. These increased levels of the deacetylating enzyme were associated with the reductions in histone acetylation and expression levels of key learning-related genes.