Wednesday, December 26, 2012

Alzheimer's Disease: Inflammation as a new therapeutic approach

Alzheimer's Disease: Inflammation as a new therapeutic approach: The number of Alzheimer's patients will continue to dramatically increase in the next several decades. Various teams of researchers worldwide are feverishly investigating precisely how the illness develops. A team of scientists under the guidance of the University of Bonn and University of Massachusetts (USA) and with the participation of the German Center for Neurodegenerative Diseases have discovered a new signaling pathway in mice which is involved in the development of chronic inflammation which causes nerve cells in the brain to malfunction and die off. The results are now being published in the renowned scientific journal "

Tuesday, December 25, 2012

Connecting two culprits in Alzheimer’s disease : Nature News Blog

Connecting two culprits in Alzheimer’s disease : Nature News Blog: Plaques and tangles pockmark the brains of people with Alzheimer’s disease. The extracellular protein amyloid-β makes plaques, and the intracellular protein tau makes tangles, but how exactly these might kill neurons is unclear. Work presented at the annual meeting of the American Society for Cell Biology in San Francisco, California, this week starts to connect some of these dots.

Wednesday, December 19, 2012

Coconut oil, Alzheimer’s disease, Seizures, Autism and more | Dr. Arturo M. Volpe

Coconut oil, Alzheimer’s disease, Seizures, Autism and more | Dr. Arturo M. Volpe: As I mentioned a few months ago in this newsletter, researchers are now looking at Alzheimer’s disease as a new form of diabetes and the expressions “Type 3 Diabetes” and “Diabetes of the Brain” have been coined. More specifically, in Alzheimer’s disease the brain loses its ability to burn glucose or blood sugar for energy.

Coconut Oil and Alzheimer’s Disease | The Alliance for Natural Health USA

Coconut Oil and Alzheimer’s Disease | The Alliance for Natural Health USA: How worried should drug companies be about supplements eating into their monopoly profits? A lot—as this story will show. Please share it with anyone you know who is suffering from Alzheimer’s or is worried about it.

Conquering Alzheimers with Coconut Ketones

Conquering Alzheimers with Coconut Ketones: Patti Smith sensed something was wrong. Her mind seemed to go into a fog at times. She would fumble for words, forget appointments, and often stopped abruptly in mid-sentence, forgetting what she was about to say. She was a productive worker and was one of the top sales consultants for BB&T bank in Washington, D.C. But brain fog made it increasingly difficult for her to sell bank services to corporate clients and her productivity began to wane.

Can coconut oil treat Alzheimer’s? | UC Health

Can coconut oil treat Alzheimer’s? | UC Health: The proposed cure is not one of those expensive Alzheimer’s drugs (which have marginal benefits), but rather a simple food that’s supposed to have dramatic effects on people with the disease. The food is coconut oil.

Tuesday, December 18, 2012

WHFoods: Turmeric

WHFoods: Turmeric: Growing evidence suggests that turmeric may afford protection against neurodegenerative diseases. Epidemiological studies show that in elderly Indian populations, among whose diet turmeric is a common spice, levels of neurological diseases such as Alzheimer's are very low.

Saturday, December 15, 2012

Controlling vascular disease may be key to reducing prevalence of Alzheimer's disease

Controlling vascular disease may be key to reducing prevalence of Alzheimer's disease: "Vascular risk factors to Alzheimer's disease offer the possibility of markedly reducing incident dementia by early identification and appropriate medical management of these likely precursors of cognitive deterioration and dementia," says Guest Editor Jack C. de la Torre, MD, PhD, of the University of Texas, Austin. "Improved understanding coupled with preventive strategies could be a monumental step forward in reducing worldwide prevalence of Alzheimer's disease, which is doubling every 20 years."

Elevated BP May Prematurely Age The Brain « CBS Philly

Elevated BP May Prematurely Age The Brain « CBS Philly: Researchers say the early changes seen with higher blood pressure may set the stage for problems with thinking, memory, and dementia down the road.
“This is an important finding,” says Paul Rosenberg, MD, associate professor of psychiatry and behavioral sciences at Johns Hopkins University in Baltimore, Md.

Walnuts lower risk of Alzheimer’s disease--study | TheMedGuru

Walnuts lower risk of Alzheimer’s disease--study | TheMedGuru: A new study claims eating small portions of the nuts regularly may play a beneficial role in supporting cognitive function and delaying the onset of the rapid memory decline in elderly people.
According to experts, the vitamin E and flavonoids found in walnuts can help stave off the harmful free radical chemicals that are known to cause dementia, the degenerative condition which is characterized by a progressive deterioration in cognitive function and the ability to process thought intelligently.

Thursday, December 13, 2012

PET, MRI, Cerebrospinal Analysis Best for Alzheimer’s Test - Diagnostic Imaging

PET, MRI, Cerebrospinal Analysis Best for Alzheimer’s Test - Diagnostic Imaging: Researchers assessed 97 patients with mild cognitive impairment (MCI) who underwent MRI, FDG-PET, and cerebrospinal fluid testing for fluid proteins. The results were compared to cognitive outcomes at two to three years.
Researchers found that by combining all three tests they were able to increase the accuracy of predicting conversion to Alzheimer’s disease over clinical testing alone. There was the added benefit of a decrease in false classifications, from 41.3 percent to 28.4 percent.

Thursday, December 6, 2012

"Brain pacemaker" offers new hope to Alzheimer's patients - CBS News

"Brain pacemaker" offers new hope to Alzheimer's patients - CBS News: A surgical procedure may offer new hope for those suffering from Alzheimer's disease, according to scientists at Johns Hopkins University. Johns Hopkins researchers recently implanted the same brain pacemaker that has been used to effectively treat tens of thousands of patients with Parkinson's disease in a patient with Alzheimers.

Tuesday, December 4, 2012

Novel Antibodies for Combating Alzheimer’s and Parkinson’s Disease | ScienceBlog.com

Novel Antibodies for Combating Alzheimer’s and Parkinson’s Disease | ScienceBlog.com: Antibodies developed by researchers at Rensselaer Polytechnic Institute are unusually effective at preventing the formation of toxic protein particles linked to Alzheimer’s disease and Parkinson’s disease, as well as Type 2 diabetes, according to a new study.

Friday, November 30, 2012

Alzheimer's may have a genetic component: scientists - New York Daily News

Alzheimer's may have a genetic component: scientists - New York Daily News: Researchers said Tuesday they had seen the earliest-ever warning signs of Alzheimer's Disease -- among a high-risk group of 20-somethings -- in the ongoing quest for early detection and prevention.
A major problem in the search for a cure for this debilitating form of dementia is that symptoms appear years after irreversible brain decay has already set in.

Alzheimer's Signs Found in Brains of Young Adults With Gene Mutation - US News and World Report

Alzheimer's Signs Found in Brains of Young Adults With Gene Mutation - US News and World Report: Scientists have discovered the earliest known evidence of Alzheimer's disease in people with a gene mutation that causes a rare form of the disease that begins at a young age.
The findings from the two studies could improve understanding of how and why Alzheimer's progresses and possibly lead to earlier detection of the disease and improved treatments, according to the researchers.

Diet Of Walnuts, Blueberries Improve Cognition; May Help Maintain Brain Function

Diet Of Walnuts, Blueberries Improve Cognition; May Help Maintain Brain Function: Scientists are confirming that this age-old adage is worth following. And new studies show that diet may have implications for those who suffer from certain brain ailments.
Diets containing two percent, six percent, or nine percent walnuts, when given to old rats, were found to reverse several parameters of brain aging, as well as age-related motor and cognitive deficits, says James Joseph, PhD, of the U.S. Department of Agriculture Human Nutrition Research Center at Tufts University in Boston.

Diabetes Treatment Shown to Improve Memory For Alzheimer’s Patients | WebProNews

Diabetes Treatment Shown to Improve Memory For Alzheimer’s Patients | WebProNews: A new study shows that a drug used to treat insulin resistance in diabetics could improve cognitive performance in some people with Alzheimer’s disease.
In the study, published this week in the Journal of Neuroscience, the drug rosiglitazone was used on mice that have been genetically engineered to serve as models for Alzheimer’s disease. Researchers found that treatment with the drug improved learning and memory in the mice, while it also normalized insulin resistance.



(Note: this happens to be a dangerous drug with a lot of side effects for some.)

Targeting inflammation improves Alzheimer's disease - Hartford health | Examiner.com

Targeting inflammation improves Alzheimer's disease - Hartford health | Examiner.com: Increased inflammation is thought to be a consequence as well as a cause of Alzheimer's disease. There is a correlation between the level of IL-12 and IL-23 (two pro-inflammatory cytokines) in the spinal fluid and cognitive performance in patients with Alzheimer’s disease. But, it is unclear whether IL-12 and IL-23 contribute to Alzheimer's disease pathogenesis.

Wednesday, November 28, 2012

A new way to treat Alzheimer's Disease may prevent or reverse mental decline - latimes.com

A new way to treat Alzheimer's Disease may prevent or reverse mental decline - latimes.com: A biological medication already widely used to treat plaque psoriasis may be able to slow the accumulation of amyloid plaques in the brain that are the hallmark of Alzheimer's disease, a new study has found. The same study found that in older mice with established Alzheimer's, this treatment approach, which suppresses the brain's immune reaction to beta amyloid, brought a marked improvement in cognitive function and may even halt or reverse early signs of Alzheimer's.

Friday, November 16, 2012

Feed your brain well to combat Alzheimer's disease

Feed your brain well to combat Alzheimer's disease: In the new book, “The Alzheimer’s Prevention Cookbook: Recipes to Boost Brain Health,” the geriatric neurologist has created a dietary plan designed to empower readers to think and cook in a way that can reduce Alzheimer’s, dementia and memory loss.

Monday, November 12, 2012

Almonds called good choice to reduce Alzheimer's risk

Almonds called good choice to reduce Alzheimer's risk | [primary-term] content from Western Farm Press: New studies give the term “health nut” new meaning, as they tie the consumption of nuts with a lower risk of Alzheimer's disease and sudden heart attacks.
Two studies published in the Journal of the American Medical Association suggest the antioxidant vitamin E and other antioxidants in nuts, leafy green vegetables and other foods — not supplements — may reduce the risk of Alzheimer's.

Factsheet for autism therapy: essential fatty acids

Factsheet for autism therapy: essential fatty acids (EFA) | Healing Thresholds: Essential fatty acids (EFAs) are compounds that cannot be made by the body, but are required for many crucial biochemical processes. There are two groups of EFAs: omega-6 and omega-3. The relative levels of these two groups of EFAs are critical to the health and development of the brain and the body. If the level of omega-6 is much higher than the level of omega-3 in the diet, there can be negative effects on cognition, mood, and behavior

New Approach Could Transform Alzheimer’s Treatment

New Approach Could Transform Alzheimer’s Treatment: Canadian researchers using computer-aided drug design have discovered a technique that could lead to new treatment options for those with Alzheimer's disease (AD).
Dalhousie University scientists successfully identified molecules that can prevent the accumulation of both beta-amyloid and tau—two proteins thought to cause the disease and disrupt patients’ ability to think and remember.
The biochemistry of Alzheimer’s is not well understood, but current drugs only work to mask its symptoms. This breakthrough, published in the Canadian Journal of Chemistry, could reveal ways to treat the underlying causes of AD and delay the cell damage it causes.

Nuts and your heart: Eating nuts for heart health - and Alzheimer's

Nuts and your heart: Eating nuts for heart health - MayoClinic.com: Nuts and your heart: Eating nuts for heart health

Saturday, November 10, 2012

Remarkable recent discoveries in Alzheimer’s disease

Remarkable recent discoveries in Alzheimer’s disease - Honolulu Health Care | Examiner.com: Dr. Eric M. Reiman, the first author on this recent study, published his results in Lancet Neurology on November 6, 2012. His research group from the Banner Alzheimer’s Institute in Phoenix, Arizona studied about 5000 people who carry the gene mutation that produces Alzheimer’s disease as early as age 45 years in Colombia.

Vitamin D2 could hold vital key to arresting development of Alzheimer's disease

Vitamin D2 could hold vital key to arresting development of Alzheimer's disease: Working in collaboration with researchers from Brighton and Sussex Medical School and the Sussex Partnership NHS Foundation, the Kingston researchers spent six months analysing blood samples from patients with Alzheimer's. They compared test results from those not being treated with any drugs to those from people on medication and a further group who did not have the condition.

Saturday, October 27, 2012

Hormone therapy may cut Alzheimer's risk in menopausal women

Hormone therapy may cut Alzheimer's risk in menopausal women - Chicago Tribune: The latest data from a long-running study of hormone therapy suggests women who started taking hormone replacements within five years of menopause were 30 percent less likely to develop Alzheimer's disease than women who started years later.
The findings, reported on Wednesday in the journal Neurology, add to evidence suggesting that taking hormone treatments around the time of menopause may be doing more than just helping women cope with hot flashes and night sweats.

Wednesday, October 24, 2012

Diet Rich in Carbohydrates and Sugar Could Increase Alzheimer's Risk

Diet Rich in Carbohydrates and Sugar Could Increase Alzheimer's Risk : Health : Counsel & Heal: A new research from Mayo Clinic in America suggests that older people who eat a diet rich in carbohydrates and sugar, could increase their risk of developing mild cognitive impairment by 4 times.
The research also suggests that plenty of consumption of proteins and fats could reduce the risk of cognitive decline.
Cognitive decline is a precursor to Alzheimer's disease. However, not everyone with mild cognitive impairment (MCI) develops Alzheimer's disease, lead author Rosebud Roberts, a professor in the department of epidemiology at the Mayo Clinic was quoted as saying by Mail Online.

Israeli medical device offers new Alzheimer's treatment

Israeli medical device offers new Alzheimer's treatment - chicagotribune.com: Israel-based Neuronix, which has developed a non-invasive medical device to help to treat Alzheimer's disease, expects the system to be approved by the U.S. Food & Drug Administration in late 2014.

The device, which combines electromagnetic stimulation with computer-based cognitive training, is already approved for use in Europe, Israel and several Asian countries such as Singapore.

Tuesday, October 23, 2012

Vitamin D helps reduces risk of serious diseases to include alzheimers

Vitamin D helps reduces risk of serious diseases: From October to March, the sun isn’t strong enough north of Los Angeles and Atlanta to prod your body into making much vitamin D-3. That endangers your immune system, makes you vulnerable to depression and overeating, weakens your bones and increases your risk for certain cancers. And then there’s the newest D-3 alert: Lack of vitamin D-3 in older adults is associated with cognitive decline and Alzheimer’s disease.

Physical exercise bulks up aging brains; experts repeat HRT cautions

Health roundup: Physical exercise bulks up aging brains; experts repeat HRT cautions: Exercise and aging brains: Physical exercise may be even more important than mental exercise when it comes to keeping mentally sharp in old age, a new study suggests. The study of people in their early 70s found that those who engaged in regular physical exercise, such as walking, retained bigger brains than those who were inactive. Mental exercise, such as doing crossword puzzles, did not seem to effect the brain shrinkage associated with aging, researchers say

Friday, October 19, 2012

Alzheimer’s Drugs Seek Prevention as Cures Fail

Alzheimer’s Drugs Seek Prevention as Cures Fail: Health - Businessweek: Three studies set to explore the use of experimental drugs that may become the first to change the course of Alzheimer’s disease aren’t looking to cure the illness. Their goal is to prevent it altogether.
The independent trials will begin in 2013 and run for three to five years, testing as many as five drugs in almost 1,500 volunteers who haven’t shown any of Alzheimer’s mind-altering symptoms, yet carry a strong genetic risk for the disease or display early physical evidence in the brain. A decision on the final study drug is expected in December.

Tuesday, October 16, 2012

Alzheimer's: Amyloid Eclipses Genetic Risk

Alzheimer's: Amyloid Eclipses Genetic Risk: Memory may fade faster in brains clogged by amyloid plaques than those at genetic risk of Alzheimer's disease, researchers found.
High levels of beta-amyloid protein in the brain were associated with greater decline in working memory and verbal and visual episodic memory over 18 months among cognitively normal individuals, Yen Ying Lim, MPsych, of the University of Melbourne in Victoria, Australia, and colleagues reported in the Oct. 16 issue of Neurology.

Silicon-rich mineral water backed for Alzheimer’s benefits

Silicon-rich mineral water backed for Alzheimer’s benefits: The study – published in the Journal of Alzheimer’s Disease – investigated the suggested links between exposure to aluminium and Alzheimer's disease by testing whether reduction in aluminium levels had beneficial effects on the disease.
Led by Professor Christopher Exley, from Keele University, UK, the research team’s findings suggest regular consumption of up to 1 litre a day of a silicon-rich mineral water works to remove aluminium from the bodies of people with Alzheimer’s disease, and in some individuals offers ‘clinically-significant’ protection against cognitive decline.

Alzheimer's tech spray being developed

Sky News: Alzheimer's tech spray being developed: A nanotechnology nasal spray is being developed that could transform the early detection and treatment of Alzheimer's.
The device shoots tiny magnetic particles into the nose which enter the bloodstream and are carried to the brain.
Each particle is fused to an antibody that targets and binds to rogue molecules believed to play an early role in the disease.
Magnetic resonance imaging (MRI) can detect both the particles and the molecules.
To date scientists have only tested the technique in the laboratory on human brain tissue cultures.
But if it can be shown to work in human patients it could lead to a major leap forward in managing Alzheimer's.

Can Lilly capitalize on Alzheimer's breakthrough?

Can Lilly capitalize on Alzheimer's breakthrough? | 2012-10-15 | Indianapolis Business Journal | IBJ.com: Eli Lilly and Co. has apparently made major medical history by being the first to develop a drug that alters the course of Alzheimer’s disease. But whether Lilly can be the first to make major money from a disease-altering Alzheimer’s drug is still in doubt.

Bilingualism delays Alzheimer's, says study

Bilingualism delays Alzheimer's, says study - PakTribune: For the first time, Toronto scientists have physical evidence that people who speak more than one language could delay the onset of Alzheimer's disease than their monolingual counterparts.
The researchers at St. Michael's Hospital found that bilingual people have twice as much brain damage as unilingual people before they exhibit symptoms of Alzheimer's disease.
"This is unheard of – no medicine comes close to delaying the onset of symptoms and now we have the evidence to prove this at the neuroanatomical level," said lead researcher Dr. Tom Schweizer, a neuroscientist at St. Michael's Hospital.
To conduct the study, the researchers studied the CT scans of 40 patients whose cognitive skills — including attention, memory, planning and organizational abilities — were found on testing to be similar.

Wednesday, October 10, 2012

Alzheimer's Drug Slows Memory Decline

Alzheimer's Drug Slows Memory Decline: An experimental Alzheimer’s treatment slowed memory loss by about one-third in people with mild Alzheimer's, offering hope that the drug can alter the course of the progressive disease.
Called solanezumab, the drug attaches to a protein called beta-amyloid that builds up and clumps together to form sticky plaques that riddle Alzheimer's patients' brains. The drug is designed to prevent those clumps from forming.

Monday, October 1, 2012

Food With Melatonin | LIVESTRONG.COM

Food With Melatonin | LIVESTRONG.COM: Tart cherries are a natural dietary source of melatonin. Scientists at the University of Texas Health Science Center in San Antonio found Montmorency and Balaton tart cherries contain high levels of melatonin compared to melatonin concentrations in the blood of mammals, according to research published in the "Journal of Agricultural and Food Chemistry" in October 2001.

Food Containing Melatonin | eHow.com

Food Containing Melatonin | eHow.com: Oats, sweet corn and rice are the best foods to eat for melatonin. These foods contain between 1,000 and 1,800 picograms (1,000,000 picograms = 1 milligram) of melatonin per gram.
In the oats family, eat oatmeal, cereals containing oats, nature bars, oatmeal cookies and oat bread. Sweet corn is available in can or frozen form or fresh from your local grocery store or farmer's market. Rice, both white and brown, is available at local grocery store.

Melatonin and exercise work against Alzheimer's in mice | Science Codex

Melatonin and exercise work against Alzheimer's in mice | Science Codex: The combination of two neuroprotective therapies, voluntary physical exercise, and the daily intake of melatonin has been shown to have a synergistic effect against brain deterioration in rodents with three different mutations of Alzheimer's disease.A study carried out by a group of researchers from the Barcelona Biomedical Research Institute (IIBB), in collaboration with the University of Granada and the Autonomous University of Barcelona, shows the combined effect of neuroprotective therapies against Alzheimer's in mice.

Cancer Drugs Reverse Memory Loss in Alzheimer’s Disease

GEN | News Highlights:Cancer Drugs Reverse Memory Loss in Alzheimer’s Disease: Scientists have made the unexpected discovery that two marketed anticancer drugs can dramatically restore memory in animal models of Alzheimer’s disease (AD), and may feasibly help hold back or even reverse memory loss in human AD patients.
The discovery, by researchers at Cold Spring Harbor Laboratory (CSHL) and Tsinghua University in Beijing (China), was based on studies in a fruit fly model of AD that expresses Aβ42. Yi Zhong, Ph.D., and colleagues found that Aβ42 directly activates EGFR in the brain, and that treating the AD model fruit flies with either of the EGFR inhibitors gefitinib or erlotinib reversed the memory loss that is characteristic of their AD phenotype.

Alzheimer's May be Caused by Poor Diet

foodconsumer.org - Alzheimer's May be Caused by Poor Diet: Can You Eat Your Way to Alzheimer's?
In a recent animal study, researchers from Brown University in Providence, Rhode Island were able to induce many of the characteristic brain changes seen with Alzheimer's disease (disorientation, confusion, inability to learn and remember) by interfering with insulin signaling in their brains.1
Faulty insulin (and leptin, another hormone) signaling is an underlying cause of insulin resistance, which, of course, typically leads to type 2 diabetes. However, while insulin is usually associated with its role in keeping your blood sugar levels in a healthy range, it also plays a role in brain signaling. When researchers disrupted the proper signaling of insulin in the brain, it resulted in dementia.

Friday, September 28, 2012

Alzheimer’s disease = type 3 diabetes? Maybe

Blogs - Fayobserver.com - Alzheimer’s disease = type 3 diabetes? Maybe: What’s new is the thought that while diabetes doesn’t “cause” Alzheimer’s, they have the same root: an over consumption of those “foods” that mess with insulin’s many roles. (Genetics have an effect on susceptibility, as they appear to with all environmental diseases.) “Sugar is clearly implicated,” says Dr. de la Monte, “but there could be other factors as well, including nitrates in food.”

Adult stem cells can prevent Alzheimer's disease

Adult stem cells can prevent Alzheimer's disease: In the first study of its kind, researchers at Korea's leading university and the RNL Bio Stem Cell Technology Institute announced this week the results of a study that suggests an astounding possibility: adult stem cells may not only have a positive effect on those suffering from Alzheimer's disease, they can prevent the disease. Using fat-derived adult stem cells from humans [scientific term: adMSCs, or human, adipose-derived mesenchymal stem cells], researchers were able to cause Alzheimer's disease brains in animal models to regenerate. The researchers, for the first time in history, used stem cells to identify the mechanism that is key to treatment of Alzheimer's disease, and demonstrated how to achieve efficacy as well as prevention of the symptoms of Alzheimer's with adult stem cells, a "holy grail" of biomedical scientists for decades.

Thursday, September 20, 2012

Margarine: Does it Cause Alzheimer's?

Margarine: Does it Cause Alzheimer's?: A shocking new study in the scientific journal Chemical Research found that an ingredient in margarine intensifies the damaging effect of an abnormal brain protein linked to Alzheimer's. The ingredient is called diacetyl, and it is also commonly used in microwave popcorn, candies, and baked goods. Since margarine has already fallen out of favor among health experts in recent years, should we eliminate it completely from our diets?

Thursday, September 13, 2012

Vitamin C and Beta-Carotene Might Protect Against Alzheimer’s |

Vitamin C and Beta-Carotene Might Protect Against Alzheimer’s | Psych Central News: Researchers have found that the antioxidants vitamin C and beta-carotene are significantly lower in patients with mild dementia, leading to suggestions that it might be possible to influence the progress of Alzheimer’s disease through diet

Some Blood Pressure Drugs Might Help Slow Alzheimer's: Study

Some Blood Pressure Drugs Might Help Slow Alzheimer's: Study - US News and World Report: Angiotensin receptor blockers, drugs commonly taken to control high blood pressure, appear to reduce the amount of plaque in the brains of Alzheimer's patients and others, a new study shows.
These results were found when patients with high blood pressure on drugs such as losartan (Cozaar) died and underwent an autopsy. These brain plaques are a hallmark of Alzheimer's disease. Whether, however, these drug also improve mental function isn't known, the researchers added.

University Of Ulster News Release - Breakthrough in Alzheimer's Research

University Of Ulster News Release - Breakthrough in Alzheimer's Research: A drug used by diabetes sufferers could have the potential to treat neurodegenerative diseases like Alzheimer’s, a study by scientists at the University of Ulster has revealed.
Type II diabetes is a known risk factor for Alzheimer’s and it is thought that impaired insulin signalling in the brain could damage nerve cells and contribute to the disease.
Scientists believe that drugs designed to tackle Type II diabetes could also have benefits for keeping our brain cells healthy.

Friday, April 27, 2012

Old Medicine May Have New Role in Alzheimer's

Old Medicine May Have New Role in Alzheimer's | Health | English: A new study in laboratory animals suggests a promising new avenue for treating Alzheimer's Disease.
The mice in this research were given a medicine that's been around for decades.

Immune globulin - also called gamma globulin - is made from purified blood plasma and is normally used to boost the immune system

Thursday, April 26, 2012

Berries May Delay Memory Decline

Berries May Delay Memory Decline: The latest target of interest is berries. A study of more than 16,000 women over age 70 suggests there is a connection between berries and memory problems. Specifically, women who ate the most berries per week were likely to have up to a 2.5-year advantage in terms of when they showed signs of memory decline.

Tuesday, March 27, 2012

Chronic stress may lead to Alzheimer’s

Chronic stress may lead to Alzheimer’s: Repeated stress may trigger the production and accumulation of insoluble protein aggregates that are associated with Alzheimer’s, a new study has suggested.

The aggregates are similar to neurofibrillary tangles or NFTs, modified protein structures that are one of the physiological hallmarks of Alzheimer’s disease.

Friday, March 23, 2012

Brain insulin resistance contributes to cognitive decline in Alzheimer's disease

Brain insulin resistance contributes to cognitive decline in Alzheimer's disease: Insulin resistance in the brain precedes and contributes to cognitive decline above and beyond other known causes of Alzheimer's disease, according to a new study by researchers from the Perelman School of Medicine at the University of Pennsylvania. Insulin is an important hormone in many bodily functions, including the health of brain cells. The team identified extensive abnormalities in the activity of two major signaling pathways for insulin and insulin-like growth factor in non-diabetic people with Alzheimer's disease. These pathways could be targeted with new or existing medicines to potentially help resensitize the brain to insulin and possibly slow down or even improve cognitive decline.

New hope for treating Alzheimer's Disease: A role for the FKBP52 protein | Science Codex

New hope for treating Alzheimer's Disease: A role for the FKBP52 protein | Science Codex: New research in humans published today reveals that the so-called FKBP52 protein may prevent the Tau protein from turning pathogenic. This may prove significant for the development of new Alzheimer's drugs and for detecting the disease before the onset of clinical symptoms.A study published online today in the Journal of Alzheimer's Disease (1), for the first time demonstrates that the FKBP52 protein, discovered by Prof. Etienne BAULIEU twenty years ago, may prevent hyperphosphorylation of Tau protein, which has been shown to characterise a number of cerebral neurodegenerative diseases, including Alzheimer's Disease (AD).

Monday, March 19, 2012

Medical Report: Potential Alzheimer's Breakthrough | ABC 6 WJBF-TV

Medical Report: Potential Alzheimer's Breakthrough | ABC 6 WJBF-TV: It's long been the holy grail for doctors treating Alzheimer's: find a way to stop the rapid mental decline that is the hallmark of this debilitating disease.
Now a new clinical trial could just prove that possible, using a novel approach that could awaken memory circuits in the brain.
It's called Deep Brain Stimulation and it has already shown promise in a few Canadian patients with early Alzheimer's.
Four years ago Robert Linton had 2 electrodes implanted in the memory area of the brain. Every day since, a battery implanted in his chest has sent his brain more than 100 electrical impulses a second.

Thursday, March 8, 2012

Vitamin D may help treat Alzheimer's disease

Vitamin D may help treat Alzheimer's disease: Scientists have identified the intracellular mechanisms regulated by vitamin D3 that may help the body clear the brain of amyloid beta, the main component of plaques associated with Alzheimer's disease.

The findings revealed that vitamin D3 may activate key genes and cellular signalling networks to help stimulate the immune system to clear the amyloid-beta protein.

Previous laboratory work by the team demonstrated that specific types of immune cells in Alzheimer's patients might respond to therapy with vitamin D3 and curcumin, a chemical found in turmeric spice, by stimulating the innate immune system to clear amyloid beta. But the researchers didn't know how it worked.

Thursday, March 1, 2012

Scientists Show How to Remove Gene Blockade and Boost Cognition in Alzheimer Disease

GEN News Highlights:Scientists Show How to Remove Gene Blockade and Boost Cognition in Alzheimer Disease: Scientists say histone deacetylase 2 (HDAC2)-selective inhibitors may represent a therapeutic approach to slowing cognitive decline in patients with neurodegenerative disorders such as Alzheimer disease (AD). Researchers at the Massachusetts Institute of Technology’s (MIT) Picower Institute for Learning and Memory and Howard Hughes Medical Institute found increased levels of HDAC2 in two mouse models of AD and in human AD patients. These increased levels of the deacetylating enzyme were associated with the reductions in histone acetylation and expression levels of key learning-related genes.

Reversing Alzheimer’s gene ‘blockade’ can restore memory, other cognitive functions - MIT News Office

Reversing Alzheimer’s gene ‘blockade’ can restore memory, other cognitive functions - MIT News Office: MIT neuroscientists have shown that an enzyme overproduced in the brains of Alzheimer’s patients creates a blockade that shuts off genes necessary to form new memories. Furthermore, by inhibiting that enzyme in mice, the researchers were able to reverse Alzheimer’s symptoms.

Wednesday, February 29, 2012

FDA adds diabetes, memory loss warnings to statins | Reuters

FDA adds diabetes, memory loss warnings to statins Reuters: Health regulators are adding warnings to the labels of widely used cholesterol lowering drugs, such as Lipitor, to say they may raise levels of blood sugar and could cause memory loss.

Blood sugar treatment may protect brain cells from Alzheimer's - Mirror Online

Blood sugar treatment may protect brain cells from Alzheimer's - Mirror Online: Alzheimer's disease could be cured by preventing low blood sugar in the brain, scientists revealed yesterday.
They experimented on mice using a chemical to maintain the supply of blood glucose to brain cells – and found it helped tostop dementia.
Chemical biologist Prof David Vocadlo and his team at the Simon Fraser University in Canada, genetically programmed mice to develop Alzheimer’s before injecting them with the chemical called Thiamet-G.

Walnuts May Boost Memory and Improve Cognitive Function: New Results from Landmark... -- FOLSOM, Calif., Feb. 29, 2012 /PRNewswire/ --

Walnuts May Boost Memory and Improve Cognitive Function: New Results from Landmark... -- FOLSOM, Calif., Feb. 29, 2012 /PRNewswire/ --: The study reported regular consumption of walnuts, but not of other nuts, was associated with better working memory. The investigators believe that the high polyphenol (antioxidant) content found in walnuts may be one of the key elements in helping to preserve cognition and fight age-related cognitive decline. Coffee, virgin olive oil and wine were also associated with better cognitive scores.

Monday, February 27, 2012

Anti-oxidant Therapy Presents a Promising Strategy in Prevention or Delaying the Onset and Progression of Alzheimer - seattlepi.com

Anti-oxidant Therapy Presents a Promising Strategy in Prevention or Delaying the Onset and Progression of Alzheimer - seattlepi.com: A newly published study, in Free Radical Biology and Medicine, provides direct evidence between increased oxidative damage and pathological responses in early memory deficits (pre-plaque) stage of Alzheimer Disease. Nutri-Med Logic Corp, agreeing with this study, adds that inadequate anti-oxidant defense is a precedent condition in Alzheimer, thus, highlighting the importance of an early anti-oxidant diet, as a therapeutic intervention. However, an early anti-inflammatory diet would be as important as the anti-oxidant diet.

Researchers test sugary solution to Alzheimer’s

Researchers test sugary solution to Alzheimer’s: Slowing or preventing the development of Alzheimer’s disease, a fatal brain condition expected to hit one in 85 people globally by 2050, may be as simple as ensuring a brain protein’s sugar levels are maintained.

Medical News:Reduced Omega-3 Speeds Brain Aging - in Neurology, Dementia from MedPage Today

Medical News:Reduced Omega-3 Speeds Brain Aging - in Neurology, Dementia from MedPage Today: Lower blood levels of omega-3 fatty acids are associated with smaller brain volumes and worse cognitive performance, researchers reported.
The structural findings suggest that people with low levels of the nutrients -- found mainly in fish -- have brains that appear to have aged faster than normal, according to Zaldy Tan, MD, of the University of California Los Angeles, and colleagues.

Thursday, February 23, 2012

foodconsumer.org - Red grape juice may help fight Alzheimer's disease

foodconsumer.org - Red grape juice may help fight Alzheimer's disease: Thursday Fed 22, 2012 (foodconsumer.org) -- A new study in Journal of Isfahan Medical School in Iran suggests that eating red grapes or drinking red grape juice regularly can help fight Alzheimer's disease.

Alzheimer's drug may impair memory | Fox News

Alzheimer's drug may impair memory Fox News: A class of drugs being investigated to treat Alzheimer's disease may actually have the opposite effect of the original intent — they may impair memory, a new study in animals suggests.
The drugs, known as BACE1 inhibitors, are designed to prevent the formation of the protein plaques in the brain that are a hallmark of Alzheimer's disease. However, the new study suggests these drugs interfere with the brain's wiring, potentially affecting the formation of new memories.

Alzheimer's Disease: Skin Cancer Drug Sparks Hope, Desperation - ABC News

Alzheimer's Disease: Skin Cancer Drug Sparks Hope, Desperation - ABC News: Because bexarotene is already approved by the U.S. Food and Drug Administration for skin cancer, doctors can legally prescribe it "off-label" for other conditions. But Alzheimer's experts urge families to temper their hope until the drug is proved safe and effective by years of clinical trials -- a tall order for the country's 5.4 million patients and 14.9 million caregivers.

Wednesday, February 22, 2012

Why I've created this blog.

My father, grandfather, and at least one uncle had Alzheimer’s.  I’m not afraid of dying; but I am afraid of Alzheimer’s.  You can find information about me in my first posting.  Alzheimer’s is not my expertise; but I do know something about research and I keep up on the news.  This is where you can find what appears to be credible research and news.  Subscribe to the blog and become a follower to keep up on the latest information and news, both good and bad.
Both my father and grandfather and possibly an uncle died with alzheimer's.   Please use this as a place for discussions and questions and answers.

Friday, February 10, 2012

A Cancer Drug Reverses Alzheimer's Disease in Mice | Healthland | TIME.com

A Cancer Drug Reverses Alzheimer's Disease in Mice Healthland TIME.com: Researchers at Case Western Reserve University have discovered that a drug currently used to treat cancer patients can reverse the cognitive deficits related to Alzheimer’s disease in mice, and what’s more, it accomplishes this feat in a remarkably short period of time.
The drug, called bexarotene, has been approved for the treatment of a type of skin cancer since 1999. In the new experiments with genetically engineered mice, the drug quickly cleared away the beta-amyloid plaques in the brain that are believed to cause cognitive deficits in Alzheimer’s disease.

Thursday, February 9, 2012

Electric shocks to brain may boost memory: Study - HealthPop - CBS News

Electric shocks to brain may boost memory: Study - HealthPop - CBS News: The study recorded brain activity in seven epilepsy patients who had already had electrodes implanted in their brains to monitor the origin of their seizures. These patients played a video game in which they had to learn the location of stores in a virtual city. UCLA neuroscientists found that participants remembered the locations better after they received mild zaps of electricity in their brains.

Saturday, February 4, 2012

A New Target In Fighting Brain Diseases: Metals - WSJ.com

A New Target In Fighting Brain Diseases: Metals - WSJ.com: Iron and copper appear to accumulate beyond normal levels in the brains of people with these diseases, and a new, Australian study published Sunday shows reducing excess iron in the brain can alleviate Alzheimer's-like symptoms—at least in mice.
A genetic mutation related to regulating iron is linked to ALS, or Lou Gehrig's disease. Zinc, on the other hand, appears to impair memory if its levels get too low or if it gets into a brain region where it doesn't belong, as it can with traumatic brain injury.

Alzheimer's disease "jumps" across brain cells to spread - HealthPop - CBS News

Alzheimer's disease "jumps" across brain cells to spread - HealthPop - CBS News: The study found that tau protein, which indicates the fibrous tangles found in the brains of Alzheimer's patients, spreads along the brain's neurons from one region to the other - resulting in severe dementia. The new clues to the neurodegenerative brain disorder might help scientists find a way to stop the disease from getting worse.

Lilly Alzheimer's drug an unlikely ace in the hole | Reuters

Lilly Alzheimer's drug an unlikely ace in the hole Reuters: Lilly's latest contender, solanezumab, is designed to bind to and mop up a protein called amyloid beta, the main component of amyloid plaque deposits in the brains of patients with Alzheimer's disease.
Anticipation over the drug has built up slowly. Lilly is expected to release as soon as this summer final data from two 18-month studies of the treatment. Earlier this week, the company said an independent safety monitor had given researchers the green light to continue with the late-stage trials.

Wednesday, February 1, 2012

Sharjah discoveries could help fight Alzheimer's and breast cancer - The National

Sharjah discoveries could help fight Alzheimer's and breast cancer - The National: SHARJAH // Chemical compounds that could combat the cells responsible for Alzheimer's disease and breast cancer have been discovered in a groundbreaking research project by local academic institutions.
Two separate three-year studies conducted by the University of Sharjah, the Sharjah Medical Research Institute and the Sharjah Academy for Scientific Research have found 15 compounds that have the potential to fight cells that cause Alzheimer's and three compounds that could combat cells responsible for the progression of breast cancer.

Wednesday, January 25, 2012

Researchers replicate Alzheimer's disease neurons with stem cells | Fox News

Researchers replicate Alzheimer's disease neurons with stem cells Fox News: Scientists have successfully replicated Alzheimer’s disease neurons with stem cells for the first time in a landmark, multi-year study – an achievement that may lead to critical new understanding of the disease, the scientists said.

Monday, January 23, 2012

Keeping brain sharp may ward off Alzheimer's protein - baltimoresun.com

Keeping brain sharp may ward off Alzheimer's protein - baltimoresun.com: People who challenge their brains throughout their lifetimes -- through reading, writing and playing games -- are less likely to develop protein deposits in the brain linked with Alzheimer's, U.S. researchers said on Monday.

Prior studies have suggested that people who are well educated and stay mentally active build up brain reserves that allow them to stay sharp even if deposits of the destructive protein called beta amyloid form in the brain.

Friday, January 20, 2012

Study identifies a new way brain cells die in Alzheimer's disease

Study identifies a new way brain cells die in Alzheimer's disease: A new study challenges conventional thinking about how brain cells die in Alzheimer’s disease. The findings demonstrate a previously unknown mechanism by which the cells die and will help lead researchers in new directions for treating the degenerative brain disease. The study by scientists at the University of Calgary’s Hotchkiss Brain Institute is published this week in the prestigious journal Proceedings of the National Academy of Sciences (PNAS).

Alzheimer's possible link to depression studied - Saskatchewan - CBC News

Alzheimer's possible link to depression studied - Saskatchewan - CBC News: Saskatchewan's leading dementia researcher is looking into possible genetic links between depression and Alzheimer's disease.
Dr. Darrell Mousseau is hoping to find a way to determine which people with depression may go on to get Alzheimer's.

Thursday, January 5, 2012

Coconut Oil Touted as Alzheimer's Remedy - Health & Science - CBN News - Christian News 24-7 - CBN.com

Coconut Oil Touted as Alzheimer's Remedy - Health & Science - CBN News - Christian News 24-7 - CBN.com: An estimated 5.4 million people in the U.S. have been diagnosed with Alzheimer's disease and that number is expected to increase exponentially as baby boomer generation enters their golden years.
But for some people, coconut oil has proven to slow the progression of Alzheimer's and may have even prevented it.