NLRP3 is activated in Alzheimer/'s disease and contributes to pathology in APP/PS1 mice : Nature : Nature Publishing Group

NLRP3 is activated in Alzheimer/'s disease and contributes to pathology in APP/PS1 mice : Nature : Nature Publishing Group: Deposition of amyloid-β peptide drives cerebral neuroinflammation by activating microglia1, 2. Indeed, amyloid-β activation of the NLRP3 inflammasome in microglia is fundamental for interleukin-1β maturation and subsequent inflammatory events3. However, it remains unknown whether NLRP3 activation contributes to Alzheimer’s disease in vivo.