Novel herbal compound offers potential to prevent and treat Alzheimer's disease: Administration of the active compound tetrahydroxystilbene glucoside (TSG) derived from the Chinese herbal medicine Polygonum multiflorum Thunb, reversed both overexpression of α-synuclein, a small protein found in the brain, and its accumulation using a mouse model of Alzheimer's disease. These results, which may shed light on the neuropathology of AD and open up new avenues of treatment, are available in the current issue of Restorative Neurology and Neuroscience.
Aberrant accumulation of α-synuclein can form insoluble aggregates that have been implicated in several neurodegenerative diseases, including Parkinson's disease, dementia with Lewy bodies, and Alzheimer's disease (AD). Researchers have now found that overexpression of α-synuclein increases with age and have demonstrated that α-synuclein aggregates in the hippocampus of older mice compared to normal controls.
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